Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug Development. COVID19-NMR Consortium. Angew Chem Int Ed Engl. 2022 Nov 14;61(46):e202205858. doi: 10.1002/anie.202205858.
G.A. Spyroulias’ Group
Binding Adaptation of GS-441524 Diversifies Macro Domains and Downregulates SARS-CoV-2 de-MARylation Capacity.
Binding Adaptation of GS-441524 Diversifies Macro Domains and Downregulates SARS-CoV-2 de-MARylation Capacity. Tsika AC, Gallo A, Fourkiotis NK, Argyriou AI, Sreeramulu S, Löhr F, Rogov VV, Richter C, Linhard V, Gande SL, Altincekic N, Krishnathas R, Elamri I,...
Unveiling the Essential Role of Arkadia’s Non-RING Elements in the Ubiquitination Process.
Unveiling the Essential Role of Arkadia's Non-RING Elements in the Ubiquitination Process. Birkou M, Delegkou GN, Marousis KD, Fragkaki N, Toro T, Episkopou V, Spyroulias GA. Int J Mol Sci. 2022 Sep 13;23(18):10585. doi: 10.3390/ijms231810585.
Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications
Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications. COVID19-NMR Consortium. Front Mol Biosci. 2021 May 10;8:653148. doi: 10.3389/fmolb.2021.653148.
Deciphering the Nucleotide and RNA Binding Selectivity of the Mayaro Virus Macro Domain
Deciphering the Nucleotide and RNA Binding Selectivity of the Mayaro Virus Macro Domain. Tsika AC, Melekis E, Tsatsouli SA, Papageorgiou N, Maté MJ, Canard B, Coutard B, Bentrop D, Spyroulias GA. J Mol Biol. 2019 May 31;431(12):2283-2297. doi:...